Fonds EPST - Papers of Sir Anthony Epstein

Identity area

Reference code

EPST

Title

Papers of Sir Anthony Epstein

Date(s)

  • 1937-2015 (Creation)

Level of description

Fonds

Extent and medium

271 boxes, 3 oversize photographs, 7 rolled items

Context area

Name of creator

(Born 1921)

Biographical history

Sir Michael Anthony Epstein was born in London on 18 May 1921 and educated at St Paul's School, London. He attended Trinity College, Cambridge, where he earned his BA in 1943, followed by an MB BChir in 1949, an MA (Cantab.) that same year, and an MD in 1951. He undertook his medical training at Middlesex Hospital Medical School, University of London. He obtained his PhD in 1952 and DSc in 1963 from the University of London, as well as an MA (Oxon.) from the University of Oxford in 1987.

Sir Anthony's first appointments were in surgery at the Middlesex Hospital and at Addenbrooke's Hospital, Cambridge in 1944, but he moved into laboratory-based medicine after his two-year service in the Royal Army Medical Corps, during which he fought in Burma and attained the rank of Captain. In 1948, he returned to the Middlesex Hospital as Assistant Pathologist at its Bland-Sutton Institute (BSI), a position he held until 1965. While working at BSI, he travelled to France and the United States, developing collaborations with Pierre Lépine at the Institut Pasteur and George Palade at the Rockefeller Institute; he also met and visited others who became influential in his career, such as Keith Porter, Francis Peyton Rous, and Gertrude and Werner Henle. At BSI and the Rockefeller, Sir Anthony developed his skills in electron microscopy, which would be essential to his discovery of the Epstein-Barr virus in 1964.

From his time at Trinity College, Sir Anthony had a keen research focus on tumour viruses; his earliest work on the Rous sarcoma virus formed the thesis research for both his MD and PHD. The decisive turning point in his career came on 22 March 1961 when he attended a talk by Dr Denis Burkitt at the Middlesex Hospital. Burkitt described a new malignant childhood lymphoma which he had observed while working as a surgeon in Uganda, speculating that the origin was a biological agent. Sir Anthony's prior work on the oncogenic Rous virus led him to decide immediately to investigate Burkitt's lymphoma for a similar viral origin.

Through a trip to East Africa supported by Burkitt and financed by the British Empire Cancer Research Campaign (now Cancer Research UK), Sir Anthony arranged for a supply of Burkitt's lymphoma biopsy samples to be sent to his laboratory at the BSI. Two pathology researchers, Dr Yvonne Barr (now Balding) and Dr Bert Achong, were recruited to work on the project. This partnership, as well as Sir Anthony's decision to grow malignant cell lines out of singular cells, led to a critical breakthrough. On 24 February 1964, Sir Anthony, Achong, and Barr observed virus particles in a Burkitt's lymphoma-derived cell for the first time. This new 'herpes-type' agent, later named the Epstein-Barr virus (EBV), is now known to infect some 90 percent of individuals in the United Kingdom before adulthood.

Sir Anthony was promoted to Head of the Department of Pathology at the BSI, but left the institute to take up a Professorship in Pathology at the University of Bristol three years later. He retired from this position in 1985. During this time, Sir Anthony and his collaborators identified EBV as the causative agent of infectious mononucleosis (IM; or glandular fever) and an important causative factor in the development of Burkitt's lymphoma and nasopharyngeal carcinoma. He also spearheaded proposals for the development of a vaccine against EBV, a cause which received support from the Cancer Research Campaign (now Cancer Research UK) and the Medical Research Council. After his retirement, Sir Anthony became Emeritus Professor of Pathology at Nuffield Department of Clinical Medicine, University of Oxford, and a Fellow of Wolfson College, Oxford. Work on the EBV vaccine continued to gain traction. By 2004, successful Phase I, Phase II, and double-blind placebo trials of a vaccine prototype had been completed. In 2005, it was discovered that this prototype could effectively protect against IM. According to Sir Anthony, his role in co-ordinating preliminary planning for human trails of the EBV vaccine was his 'final scientific contribution'.

A prolific writer in the natural sciences, Sir Anthony is the author of 252 publications in major scientific journals, as well as 6 books. He was the joint founder editor of the International Review of Experimental Pathology, 1980–1986, a member of the editorial boards of eight international scientific journals, and an advisor or reviewer for twenty other journals. Sir Anthony made frequent appearances in the media and often engaged with the public on his research through interviews, correspondences, and contributions to educational materials. He has received many honours, awards, and prizes throughout his life. Sir Anthony was made a Commander of the British Empire (CBE) in 1985 and a Knight Bachelor in 1991.

Archival history

The papers were deposited by Sir Anthony Epstein with the Centre for Scientific Archives for the production of a finding aid in 2016. They were then placed in storage under the National Conservation Service Scheme, and were finally transferred to Trinity in 2022.

Immediate source of acquisition or transfer

Content and structure area

Scope and content

These papers consist of material from throughout Sir Anthony's scientific career. They include personal materials, professional diaries, laboratory research notebooks and electron micrograph images, working papers and professional correspondence, documents and illustrations related to publications and presentations, and paper reprints.

Series A: Personal Material contains personal materials belonging to Sir Anthony. These items include personal photographs, gifts and mementos, newspaper cuttings, taped lectures and interviews, professional and academic certificates, and other items commemorating the honours Sir Anthony received throughout this career.

Series B: Professional Diaries, Address Book, and Shorthand Notebooks contains Sir Anthony's professional appointment diaries at the Bland-Sutton Institute at the Middlesex Hospital, the Department of Pathology at the University of Bristol, the Nuffield Department of Clinical Medicine at the University of Oxford, and Wolfson College, Oxford. Sub-series B/5 is a collection of shorthand notebooks from 1981–1987.

Series C: Laboratory Research Notebooks and Photographic Material contains Sir Anthony and his collaborators' laboratory notebooks, along with images of experiments. The notebooks detail a number of techniques for growing malignant cells, isolating the Epstein-Barr virus, and imaging experimental samples. Sub-series C/2 contains three notebooks belonging to Dr Bert G. Achong. Achong co-discovered the Epstein-Barr virus alongside Sir Anthony and Dr Yvonne Balding (née Barr) using electron microscopy imaging techniques. Sub-series C/7 contains photographs and negatives of experiments.

Series D: Working Papers and Correspondence contains papers, correspondence, and notes from Sir Anthony's lectures, meetings, conferences, and travels, as well as a range of files relating to Sir Anthony's professional life. It provides a broad as well as in-depth picture of Sir Anthony's working life. Main aspects dealt with include: historical significance of the Epstein-Barr virus, advisory and consultation work, the wide spectrum of research work, general correspondence, personal matters, publications and broadcasting, and professional and academic societies and organizations. More detailed summaries about the papers are available in each sub-series description. Types of papers include correspondence, reports, and discussion, working, and meeting papers.

Series E: Publications and Papers Presented contains materials related to publications and presentations developed from Sir Anthony's research. These include theses and publications by Sir Anthony and researchers in his laboratories, review papers, book contributions, and illustrations for publications and presentations.

Series F: Reprints and Journal References contains a range of material related to reprints of Sir Anthony's journal publications. In the sciences, reprints (or offprints) are often kept by authors for distribution to collaborators and peers. Sir Anthony kept a numbered file of reprints, in order of publication. These collected reprints are contained in this series, as well as reprint request slips, and a list of reprint recipients. Sub-series F/5 is an index of papers references by Sir Anthony in his publications.

Appraisal, destruction and scheduling

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Conditions of access and use area

Conditions governing access

Not all the material in this collection may yet be available for consultation. Enquiries should be addressed in the first instance to:

The Archivist
Trinity College Library
Cambridge
Cambridge
CB2 1TQ

archives@trin.cam.ac.uk

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Notes area

Note

Catalogued by Celia Cassingham for the Centre for Scientific Archives, 2016.

Alternative identifier(s)

CSA

184/2/2016

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Archivist's note

The current record was created using the Centre for Scientific Archives finding aid, and was edited by Leena Hamad and Rebecca Hughes in 2022.

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